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Review
. 2011 Apr;34(4):312-6.
doi: 10.1007/BF03347092. Epub 2011 Mar 15.

Resistant prolactinomas

V Vasilev  1 , A F Daly, L Vroonen, S Zacharieva, A Beckers
Affiliations
Review

Resistant prolactinomas

V Vasilev et al. J Endocrinol Invest. 2011 Apr.

Abstract

Prolactinomas are the most common hormonally active pituitary tumors and are usually successfully treated with dopamine agonists. A small proportion, however, appears not to respond to such treatment and such cases are termed resistant prolactinomas. Resistance is generally defined as failure to achieve normoprolactinemia and inability to induce tumor shrinkage. Reduced dopamine receptor density on lactotroph cells is currently considered the major underlying mechanism of resistance. Treatment options in resistant cases usually include substitution with another dopamine agonist, increasing the dose of the drug, as well as surgery, radiotherapy, and experimental medical therapies.

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