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. 2011 Apr 26;104(9):1487-92.
doi: 10.1038/bjc.2011.90. Epub 2011 Mar 15.

Fluid intake and incidence of renal cell carcinoma in UK women

N E Allen  1 , A Balkwill, V Beral, J Green, G Reeves; Million Women Study Collaborators
Collaborators, Affiliations

Fluid intake and incidence of renal cell carcinoma in UK women

N E Allen et al. Br J Cancer. .

Abstract

Background: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women.

Methods: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.

Results: After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779,369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages.

Conclusions: The apparent protective effect of alcohol on the risk of renal cell carcinoma is unlikely to be related to a high fluid intake.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of total fluid intake among 779 369 women in the Million Women Study.
Figure 2
Figure 2
Multivariate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma per drink per day increase according to various characteristics of the women studied.
See this image and copyright information in PMC

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