doi: 10.1039/c1cc10172b.
Epub 2011 Mar 15.
Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes
Affiliations
- PMID: 21409237
- DOI: 10.1039/c1cc10172b
Item in Clipboard
Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes
Chem Commun (Camb).
.
Abstract
A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
© The Royal Society of Chemistry 2011
Similar articles
-
From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons.Angew Chem Int Ed Engl. 2007;46(6):966-8. doi: 10.1002/anie.200604027. Angew Chem Int Ed Engl. 2007. PMID: 17167807 No abstract available.
-
Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications.Acc Chem Res. 2009 Jul 21;42(7):822-31. doi: 10.1021/ar800192p. Acc Chem Res. 2009. PMID: 19534516 Review.
-
Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents.Chem Commun (Camb). 2008 Feb 7;(5):600-2. doi: 10.1039/b715383j. Epub 2007 Nov 26. Chem Commun (Camb). 2008. PMID: 18209802
-
Osmotically shrunken LIPOCEST agents: an innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer.Chemistry. 2009;15(6):1440-8. doi: 10.1002/chem.200801766. Chemistry. 2009. PMID: 19115311
-
Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.Chem Soc Rev. 2006 Jun;35(6):512-23. doi: 10.1039/b510982p. Epub 2006 May 3. Chem Soc Rev. 2006. PMID: 16729145 Review.
Cited by
-
Redox- and hypoxia-responsive MRI contrast agents.ChemMedChem. 2014 Jun;9(6):1116-29. doi: 10.1002/cmdc.201402034. Epub 2014 May 13. ChemMedChem. 2014. PMID: 24825674 Free PMC article. Review.
-
Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging.Chem Commun (Camb). 2014 Dec 7;50(94):14835-8. doi: 10.1039/c4cc07027e. Chem Commun (Camb). 2014. PMID: 25323054 Free PMC article.
-
Analytical methods for investigating in vivo fate of nanoliposomes: A review.J Pharm Anal. 2018 Aug;8(4):219-225. doi: 10.1016/j.jpha.2018.07.002. Epub 2018 Jul 4. J Pharm Anal. 2018. PMID: 30140485 Free PMC article. Review.
-
A diaCEST MRI approach for monitoring liposomal accumulation in tumors.J Control Release. 2014 Apr 28;180:51-9. doi: 10.1016/j.jconrel.2014.02.005. Epub 2014 Feb 15. J Control Release. 2014. PMID: 24548481 Free PMC article.
-
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chem Rev. 2019 Jan 23;119(2):957-1057. doi: 10.1021/acs.chemrev.8b00363. Epub 2018 Oct 16. Chem Rev. 2019. PMID: 30350585 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
