Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Apr 28;47(16):4667-9.
doi: 10.1039/c1cc10172b. Epub 2011 Mar 15.

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

Enzo Terreno  1 , Cinzia Boffa, Valeria Menchise, Franco Fedeli, Carla Carrera, Daniela Delli Castelli, Giuseppe Digilio, Silvio Aime
Affiliations

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

Enzo Terreno et al. Chem Commun (Camb). .

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

PubMed Disclaimer

Publication types