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. 1990 Jun 15;61(6):1013-20.
doi: 10.1016/0092-8674(90)90066-n.

Renaturation of denatured lambda repressor requires heat shock proteins

G A Gaitanaris  1 , A G Papavassiliou, P Rubock, S J Silverstein, M E Gottesman
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Renaturation of denatured lambda repressor requires heat shock proteins

G A Gaitanaris et al. Cell. .

Retraction in

Abstract

The temperature-sensitive bacteriophage lambda cI857 repressor protein rapidly renatures after thermal inactivation. E. coli mutants in the heat shock protein genes dnaK, dnaJ, and grpE do not efficiently reactivate heat-denatured repressor. Our results suggest that protein refolding is promoted by heat shock proteins and that such a process is the basis of the homeostatic role played by these proteins in the heat shock response.

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