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Review
. 2011;3(3):274-9.
doi: 10.1159/000324176. Epub 2011 Mar 12.

Natural killer cell responses to viral infection

Joshua D Brandstadter  1 , Yiping Yang
Affiliations
Review

Natural killer cell responses to viral infection

Joshua D Brandstadter et al. J Innate Immun. 2011.

Abstract

Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will help develop NK cell-based therapies. In this review, we will first discuss how NK cells are activated in response to viral infections. We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells.

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References

    1. Cerwenka A, Lanier LL. Natural killer cells, viruses and cancer. Nat Rev Immunol. 2001;1:41–49. - PubMed
    1. Kiessling R, Klein E, Wigzell H. ‘Natural’ killer cells in the mouse. 1. Cytotoxic cells with specificity for mouse moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol. 1975;5:112–117. - PubMed
    1. Herberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. 1. Distribution of reactivity and specificity. Int J Cancer. 1975;16:216–229. - PubMed
    1. Karre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature. 1986;319:675–678. - PubMed
    1. Orange JS. Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect. 2002;4:1545–1558. - PubMed

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