Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology

Abstract

Aim: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis.

Methods: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment.

Results: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score.

Conclusion: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.

Keywords: Alcoholic liver cirrhosis; Child-Pugh score; Primary biliary cirrhosis; Vitamin D deficiency.

Figure 1

Vitamin D levels in the study group. Vitamin D levels in 37 patients with primary biliary cirrhosis and 89 patients with alcoholic liver cirrhosis. Patients with alcoholic liver cirrhosis demonstrated significantly lower overall vitamin D levels in comparison to patients with primary biliary cirrhosis (P < 0.0001, Mann-Whitney U test). PBC: Primary biliary cirrhosis; ALC: Alcoholic liver cirrhosis.