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Meta-Analysis
. 2011 Mar 16;2011(3):CD000436.
doi: 10.1002/14651858.CD000436.pub3.

Dietary sodium manipulation and asthma

Zara Pogson  1 , Tricia McKeever
Affiliations
Meta-Analysis

Dietary sodium manipulation and asthma

Zara Pogson et al. Cochrane Database Syst Rev. .

Abstract

Background: There is a wide geographical variation in the prevalence of asthma and observational studies have suggested that dietary sodium may play a role.

Objectives: To assess the effect of dietary sodium manipulation on asthma control.

Search strategy: We carried out a search using the Cochrane Airways Group asthma register. We searched the bibliographies of included randomised controlled trials (RCTs) for additional studies. We carried out the most recent search in November 2010.

Selection criteria: We considered only RCTs that involved dietary sodium reduction or increased sodium intake in patients with asthma.

Data collection and analysis: Both review authors assessed study and extracted data. We conducted data analyses in RevMan 5 using mean differences and random effects.

Main results: We identified a total of nine studies in relation to sodium manipulation and asthma, of which five were in people with asthma (318 participants), and four in people with exercise-induced asthma (63 participants). There were no significant benefits of salt restriction on the control of asthma. There was some evidence from the exercise-induced asthma studies that a low sodium diet may improve lung function after exercise and possibly baseline lung function, but this is based on findings from a very small numbers of participants.

Authors' conclusions: This review did not find any evidence that dietary sodium reduction significantly improves asthma control. Although dietary sodium reduction may result in improvements in lung function in exercise-induced asthma, the clinical significance of this effect is unclear.

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Conflict of interest statement

ZP and TM were both involved with the largest study reported in this review (Pogson 2008).

Figures

1
1
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
2
2
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.4 5‐minute post‐exercise FEV1 (litres).
3
3
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.1 Baseline FEV1 (litres).
4
4
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.2 Baseline FVC (litres).
5
5
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.5 5‐minute post‐exercise FVC (litres).
6
6
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.3 Baseline FEV1/FVC (%).
7
7
Forest plot of comparison: 2 Exercise induced asthma ‐ low sodium diet vs high sodium diet, outcome: 2.6 5‐minute post‐exercise FEV1/FVC (%).
1.1
1.1. Analysis
Comparison 1 Asthma ‐ low sodium diet (LSD) vs higher sodium diet (HSD), Outcome 1 FEV1 (litres).
1.2
1.2. Analysis
Comparison 1 Asthma ‐ low sodium diet (LSD) vs higher sodium diet (HSD), Outcome 2 FEV1/FVC (%).
1.3
1.3. Analysis
Comparison 1 Asthma ‐ low sodium diet (LSD) vs higher sodium diet (HSD), Outcome 3 PEFR (litres/min).
1.4
1.4. Analysis
Comparison 1 Asthma ‐ low sodium diet (LSD) vs higher sodium diet (HSD), Outcome 4 Bronchodilator usage (puffs/day).
1.5
1.5. Analysis
Comparison 1 Asthma ‐ low sodium diet (LSD) vs higher sodium diet (HSD), Outcome 5 Sodium excretion (mmol/L).
2.1
2.1. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 1 Baseline FEV1 (litres).
2.2
2.2. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 2 Baseline FVC (litres).
2.3
2.3. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 3 Baseline FEV1/FVC (%).
2.4
2.4. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 4 5‐minute post‐exercise FEV1 (litres).
2.5
2.5. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 5 5‐minute post‐exercise FVC (litres).
2.6
2.6. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 6 5‐minute post‐exercise FEV1/FVC (%).
2.7
2.7. Analysis
Comparison 2 Exercise induced asthma ‐ low sodium diet (LSD) vs high sodium diet (HSD), Outcome 7 Sodium excretion (mmol/l).
See this image and copyright information in PMC

Update of

References

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