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Review
. 2011 Jun;26(6):1776-7.
doi: 10.1093/ndt/gfr124. Epub 2011 Mar 17.

Minimal change disease as a modifiable podocyte paracrine disorder

Changli Wei  1 , Jochen Reiser
Affiliations
Review

Minimal change disease as a modifiable podocyte paracrine disorder

Changli Wei et al. Nephrol Dial Transplant. 2011 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic of systemic and glomerular pathways leading to human MCD. Literature supports the notion that T-and/or B-cell mediated events lead to a yet to be identified circulating factor that harms glomerular cells causing MCD. According to Clement et al., podocyte-derived ANGPTL4-expression is induced in MCD but insufficiently sialylated, causing disturbance of the GBM as well as endothelial cells in a paracrine fashion.
See this image and copyright information in PMC

References

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    1. Clement LC, Avila-Casado C, Mace C, et al. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 2011;17:117–122. - PMC - PubMed

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