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. 2011 Oct;140(4):881-901.
doi: 10.1378/chest.10-2133. Epub 2011 Mar 17.

Pulmonary outcomes in survivors of childhood cancer: a systematic review

Tseng-Tien Huang  1 , Melissa M Hudson  2 , Dennis C Stokes  3 , Matthew J Krasin  4 , Sheri L Spunt  2 , Kirsten K Ness  5
Affiliations

Pulmonary outcomes in survivors of childhood cancer: a systematic review

Tseng-Tien Huang et al. Chest. 2011 Oct.

Abstract

Background: The purpose of this article is to summarize the literature that documents the long-term impact of cancer treatment modalities on pulmonary function among survivors of cancer and to identify potential areas for further research.

Methods: Systematic reviews of clinical trials, observational studies, case series, and review articles were conducted. Articles were limited to the studies that discussed pulmonary toxicity or late effects among pediatric cancer survivors and to follow-up investigations that were conducted a minimum of 2 years after completion of cancer-related treatment or 1 year after hematopoietic stem cell transplant.

Results: Sixty publications (51 clinical studies/reports and nine reviews) published from January 1970 to June 2010 in PubMed met the inclusion criteria. Data showed an association between radiotherapy, alkylating agents, bleomycin, hematopoietic stem cell transplant, and thoracic surgery and pulmonary toxicity, as well as possible interactions among these modalities.

Conclusions: Pulmonary toxicity is a common long-term complication of exposure to certain anticancer therapies in childhood and can vary from subclinical to life threatening. Pulmonary function and associated loss of optimal exercise capacity may have adverse effects on long-term quality of life in survivors. Lung function diminishes as a function of normal aging, and the effects of early lung injury from cancer therapy may compound these changes. The information presented in this review is designed to provide a stimulus to promote both observational and interventional research that expands our knowledge and aids in the design of interventions to prevent or ameliorate pulmonary late effects among survivors of childhood cancer.

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Figures

Figure 1.
Figure 1.
Mechanisms for altered pulmonary function and/or growth by HSCT. BO = bronchiolitis obliterans; BOOP = bronchiolitis obliterans organizing pneumonia; CMV = cytomegalovirus; DAH = diffuse alveolar hemorrhage; HSCT = hematopoietic stem cell transplant; IPS = idiopathic pneumonia syndrome.
See this image and copyright information in PMC

References

    1. Hampton T. Cancer survivors need better care: new report makes recommendations. JAMA. 2005;294(23):2959–2960. - PubMed
    1. Horner MJ, Krapcho M, et al., editors. Bethesda, MD: National Cancer Institute; 2009. SEER Cancer Statistics Review, 1975-2006, based on November 2008 SEER data submission, posted to the SEER Web site. http://seer.cancer.gov/csr/1975_2006/. October 2009.
    1. Hewitt MWS, Simone JV, editors. Childhood Cancer Survivorship: Improving Care and Quality of Life. Washington, DC: National Academies Press; 2003. - PubMed
    1. Armstrong GT, Liu Q, Yasui Y, et al. Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J Clin Oncol. 2009;27(14):2328–2338. - PMC - PubMed
    1. Hudson MM, Mertens AC, Yasui Y, et al. Childhood Cancer Survivor Study Investigators Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003;290(12):1583–1592. - PubMed

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