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Review
. 2011 May;68(9):1481-9.
doi: 10.1007/s00018-011-0656-z. Epub 2011 Mar 17.

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

Brian P Dolan  1 , Jack R Bennink, Jonathan W Yewdell
Affiliations
Review

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

Brian P Dolan et al. Cell Mol Life Sci. 2011 May.

Abstract

It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.

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