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Review
. 2011 Jun;164(6):1201-13.
doi: 10.1111/j.1365-2133.2011.10322.x. Epub 2011 May 13.

Viral oncogenesis and its role in nonmelanoma skin cancer

S Tuttleton Arron  1 , L Jennings, I Nindl, F Rosl, J N Bouwes Bavinck, D Seçkin, M Trakatelli, G M Murphy; Viral Working Group of the International Transplant Skin Cancer Collaborative (ITSCC) & Skin Care in Organ Transplant Patients, Europe (SCOPE)
Affiliations
Review

Viral oncogenesis and its role in nonmelanoma skin cancer

S Tuttleton Arron et al. Br J Dermatol. 2011 Jun.

Abstract

In recent years, the contribution of viruses to cutaneous oncogenesis has steadily gained recognition. The archetype is human herpesvirus 8, which is well established as the causative agent in Kaposi sarcoma. Other viruses believed to play a role in nonmelanoma skin cancer include human papillomavirus and the recently described Merkel cell polyomavirus. We review the mechanisms by which these three viruses interact with the host cell, ultraviolet radiation and immunosuppression to result in carcinogenesis.

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