Erythropoietin for stroke treatment: dead or alive?
- PMID: 21418552
- PMCID: PMC3219325
- DOI: 10.1186/cc10057
Erythropoietin for stroke treatment: dead or alive?
Abstract
Endothelial progenitor cell (EPC) mobilization from the bone marrow was considered to improve outcome after ischemic stroke. Erythropoietin (EPO) might be a potential candidate stroke drug that increases the number of circulating EPCs. In the previous issue of Critical Care, Yip and colleagues investigated the effect of EPO in stroke patients on both clinical outcome and EPC stimulation. Although beneficial effects of EPO were observed, several issues regarding EPO's suitability as a stroke drug remain.
Comment in
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Effect of erythropoietin therapy on clinical outcome in patients after acute ischemic stroke: a debatable issue.Crit Care. 2011;15(3):425. doi: 10.1186/cc10145. Epub 2011 May 17. Crit Care. 2011. PMID: 21586100 Free PMC article. No abstract available.
Comment on
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Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke.Crit Care. 2011;15(1):R40. doi: 10.1186/cc10002. Epub 2011 Jan 26. Crit Care. 2011. PMID: 21269484 Free PMC article. Clinical Trial.
References
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