[The effects of combination anti-inflammatory and anti-oxidation drugs in acute stroke]

Abstract

Objective: Research the effect of anti-inflammatory and anti-oxidation drugs on acute stroke patients.

Methods: 128 patients with acute ischemic stroke are divided into two groups-combined treatment group (71) and control (57). Test serum biomarkers and evaluate neurological function and living ability before and after therapy, compare between groups and intra-group. To observe the effects of combined therapy on serum biomarkers and prognosis in acute stage.

Results: (1) MMP-9 of combined treatment group (3.23 ± 0.99) ng/L is higher than control (2.82 ± 1.21) ng/L before therapy (P < 0.05). (2) The level of pre-treatment ox-LDL-Ab in combined treatment group (0.08 ± 0.01) U/ml higher than post-treatment (0.07 ± 0.01) U/ml (P < 0.05). The level of pre-treatment NIHSS in control group (5.76 ± 6.61) score higher than post-treatment (4.22 ± 5.45) score, P < 0.05.

Conclusion: Combined treatment can degrade serum MMP-9 and ox-LDL in acute ischemic stroke patients, but it can't obviously improve the earlier prognosis.