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. 2012 Nov-Dec;30(6):856-63.
doi: 10.1016/j.urolonc.2010.08.024. Epub 2011 Mar 17.

Surgical approach and the use of lymphadenectomy and adrenalectomy among patients undergoing radical nephrectomy for renal cell carcinoma

Christopher P Filson  1 , David C Miller, Joanne S Colt, Julie Ruterbusch, W Marston Linehan, Wong-Ho Chow, Kendra Schwartz
Affiliations

Surgical approach and the use of lymphadenectomy and adrenalectomy among patients undergoing radical nephrectomy for renal cell carcinoma

Christopher P Filson et al. Urol Oncol. 2012 Nov-Dec.

Abstract

Objectives: We assessed the influence of tumor size and surgical approach on the use of lymphadenectomy and adrenalectomy with radical nephrectomy.

Methods: We evaluated patients with renal cell carcinoma (RCC) enrolled in the U.S. Kidney Cancer Study, a case-control study in the metropolitan areas of Detroit and Chicago from 2002 to 2007. We identified patients who underwent open (ORN) or laparoscopic radical nephrectomy (LRN). We used medical records and Surveillance, Epidemiology, and End Results (SEER) data to determine the proportion of patients who underwent lymphadenectomy or adrenalectomy. Bivariate analyses were performed to evaluate associations between tumor size, surgical approach, and receipt of lymphadenectomy or adrenalectomy.

Results: We identified 730 patients who underwent ORN (427, 58%) or LRN (303, 42%) for RCC from 2002 to 2007. Among this group, 11% and 24% underwent lymphadenectomy or adrenalectomy, respectively. Lymphadenectomy was more common among patients treated from an open surgical approach (14.1% ORN vs. 5.9% LRN, P < 0.01); this difference was most pronounced for cases with tumors between 4 and 7 cm (15.9% vs. 2.9%, P = 0.01). Patients treated with ORN were also more likely to undergo adrenalectomy, with the greatest discrepancy among cases with tumors ≤ 4 cm (21.7% vs. 11.4%, P < 0.01).

Conclusions: Among patients undergoing radical nephrectomy for RCC, the use of lymphadenectomy and adrenalectomy is relatively uncommon and varies by tumor size and surgical approach. With an increasing number of patients with small tumors, the diffusion of laparoscopy, and the emergence of clinical trials evaluating systemic adjuvant therapies, our findings highlight important considerations for optimizing surgical management of patients with RCC.

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Figures

FIGURE 1
FIGURE 1
Use of Lymphadenectomy Stratified by Tumor Size. *p<0.05 for comparison between open and laparoscopic radical nephrectomy
FIGURE 2
FIGURE 2
Use of Adrenalectomy Stratified by Tumor Size. *p<0.05 for comparison between open and laparoscopic radical nephrectomy
See this image and copyright information in PMC

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