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. 2011 Jun;79(1):1-5.
doi: 10.1016/j.saa.2010.12.008. Epub 2010 Dec 14.

The protective effect of salicylic acid on lysozyme against riboflavin-mediated photooxidation

Kun Li  1 , Hongbao Wang, Lingli Cheng, Hui Zhu, Mei Wang, Shi-Long Wang
Affiliations

The protective effect of salicylic acid on lysozyme against riboflavin-mediated photooxidation

Kun Li et al. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun.

Abstract

As a metabolite of aspirin in vivo, salicylic acid was proved to protect lysozyme from riboflavin-mediated photooxidation in this study. The antioxidative properties of salicylic acid were further studied by using time-resolved laser flash photolysis of 355 nm. It can quench the triplet state of riboflavin via electron transfer from salicylic acid to the triplet state of riboflavin with a reaction constant of 2.25×10(9) M(-1) s(-1). Mechanism of antioxidant activities of salicylic acid on lysozyme oxidation was discussed. Salicylic acid can serve as a potential antioxidant to quench the triplet state of riboflavin and reduce oxidative pressure.

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