Urolithiasis in a rural Wisconsin population from 1992 to 2008: narrowing of the male-to-female ratio

Abstract

Purpose: Urolithiasis is a common disease with multiple etiologies and risk factors. Studies suggest an increased incidence in developed nations in recent decades as well as differential geographic incidence and prevalence rates, and differences between the genders. We updated urolithiasis epidemiological data by examining the incidence and prevalence rates in a stable rural Wisconsin population.

Materials and methods: Data were obtained from the Marshfield Epidemiologic Study Area database, a surveillance tool created in 1991 to track disease in residents of an area of 24 ZIP Codes including approximately 85,000 individuals, of whom most receive care at Marshfield Clinic and affiliates. Urolithiasis cases were identified using ICD-9 codes. Incidence, prevalence and recurrence rates were determined.

Results: The mean age adjusted incidence of new onset urolithiasis per 100,000 person-years was 202 (95% CL 168-235) in 1992 and 289 (95% CL 253-325) in 2008. In women the increase per 100,000 person-years was higher than in men, that is 171 (95% CL 129-213) and 289 (95% CL 238-340) vs 238 (95% CL 184-290) and 296 (95% CL 244-348), respectively. The male-to-female incidence ratio decreased from 1.4 to 1.0. The age adjusted prevalence per 100,000 individuals was 1,968 (2%) and 3,554 (3.5%) in 1992 and 2008, respectively. The increase in women was higher than in men (52% vs 26%). The age adjusted recurrence rate per 100,000 individuals was 553 (0.72%) and 676 (1.0%) in 1992 and 2008, respectively. The increase in women was higher than in men (88% vs 20%).

Conclusions: Since 1992, urolithiasis incidence, prevalence and recurrence rates in this rural Wisconsin population have increased with higher increases noted in women. While prevalence increased, it was lower than reported in other geographic areas in the United States.

FIGURE 1

Overview of patient selection for the study.

FIGURE 2

Age-adjusted total incidence of urolithiasis per 100,000 person-years in MESA from 1992–2008; specific rates and 95% confidence limits are listed in Table 1.

FIGURE 3

Incidence of urolithiasis per 100,000 person-years in MESA from 1992–2008 by 5-year age groups (0–109 years).

FIGURE 4

Relative proportion (%) of incident urolithiasis in MESA within each gender by 10-year age groups, from 1992 through 2008; data for females are shown in panel A and males in panel B.