Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Feb;52(2):272-8.
doi: 10.1177/0091270010393343.

Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity

Mahmoud Abouraya  1 , James C Sacco, Kristie Hayes, Sajeve Thomas, Craig S Kitchens, Lauren A Trepanier
Affiliations
Case Reports

Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity

Mahmoud Abouraya et al. J Clin Pharmacol. 2012 Feb.
No abstract available

Keywords: Methemoglobin; N-acetylation; adverse drug reaction; arylamine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Cytochrome c reduction activity in the patient’s peripheral blood mononuclear leukocytes (measured in 2 separate assays) was lower than all values observed in 29 healthy control subjects.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Giullian JA, Cavanaugh K, Schaefer H. Lower risk of urinary tract infection with low-dose trimethoprim/sulfamethoxazole compared with dapsone prophylaxis in older renal transplant patients on a rapid steroid-withdrawal immunosuppression regimen. Clin Transplant. 2009;24:636–642. - PMC - PubMed
    1. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore) 2004;83:265–273. - PubMed
    1. Reilly T, Woster P, Svensson C. Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: implications for differences in adverse drugs reactions. J Pharmacol Exp Ther. 1999;288:951–959. - PubMed
    1. Ganesan S, Tekwani BL, Sahu R, Tripathi LM, Walker LA. Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. Toxicol Appl Pharmacol. 2009;241:14–22. - PubMed
    1. Winter HR, Wang Y, Unadkat JD. CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000;28:865–868. - PubMed

Publication types