doi: 10.1038/346147a0.
Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets
Affiliations
- PMID: 2142255
- DOI: 10.1038/346147a0
Item in Clipboard
Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets
Nature.
.
Abstract
The adenovirus E1a protein (E1a), a potent transcription activator, contains a transcriptional activating region. Compared with previously described cellular and viral activators, E1a's activating region has unusual structural properties. It seems that E1a's activating region interacts with a cellular target not required for the function of transcriptional activators with 'acidic' activating regions. By contrast, the target of an acidic activating region is required both by acidic activators and by E1a. It is proposed that the cellular target of E1a's activating region is an 'adaptor' that allows E1a to interact with the basic transcriptional machinery.
Similar articles
-
E1a revisited: the case for multiple cooperative trans-activation domains.New Biol. 1991 Jan;3(1):18-26. New Biol. 1991. PMID: 1828178 Review.
-
Transcription activation by the adenovirus E1a protein.Nature. 1989 Mar 2;338(6210):39-44. doi: 10.1038/338039a0. Nature. 1989. PMID: 2521923
-
Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI.Nature. 1989 Nov 9;342(6246):200-3. doi: 10.1038/342200a0. Nature. 1989. PMID: 2509943
-
The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB.J Mol Biol. 1996 Sep 6;261(5):599-606. doi: 10.1006/jmbi.1996.0485. J Mol Biol. 1996. PMID: 8800208
-
Cellular and viral transcriptional activators.Harvey Lect. 1992-1993;88:67-96. Harvey Lect. 1992. PMID: 1365875 Review. No abstract available.
Cited by
-
The Transcriptional Repressor BS69 is a Conserved Target of the E1A Proteins from Several Human Adenovirus Species.Viruses. 2018 Nov 22;10(12):662. doi: 10.3390/v10120662. Viruses. 2018. PMID: 30469473 Free PMC article.
-
A R2R3-MYB gene-based marker for the non-darkening seed coat trait in pinto and cranberry beans (Phaseolus vulgaris L.) derived from 'Wit-rood boontje'.Theor Appl Genet. 2020 Jun;133(6):1977-1994. doi: 10.1007/s00122-020-03571-7. Epub 2020 Feb 28. Theor Appl Genet. 2020. PMID: 32112124 Free PMC article.
-
Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.J Virol. 1994 Nov;68(11):7275-83. doi: 10.1128/JVI.68.11.7275-7283.1994. J Virol. 1994. PMID: 7933111 Free PMC article.
-
Plant activating sequences: positively charged peptides are functional as transcriptional activation domains.Nucleic Acids Res. 1994 Sep 25;22(19):3983-9. doi: 10.1093/nar/22.19.3983. Nucleic Acids Res. 1994. PMID: 7937121 Free PMC article.
-
Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.J Virol. 1996 Jun;70(6):3844-51. doi: 10.1128/JVI.70.6.3844-3851.1996. J Virol. 1996. PMID: 8648720 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
