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Comparative Study
. 1990 Jul;87(13):4912-6.
doi: 10.1073/pnas.87.13.4912.

Neurospora crassa A mating-type region

N L Glass  1 , J Grotelueschen, R L Metzenberg
Affiliations
Comparative Study

Neurospora crassa A mating-type region

N L Glass et al. Proc Natl Acad Sci U S A. 1990 Jul.

Abstract

The mating-type locus of the haploid filamentous fungus Neurospora crassa is a regulatory region that controls entry into the sexual cycle and prevents formation of mixed mating-type heterokaryons in the vegetative phase. The locus consists of alternative sequences called A and a. The A mating-type DNA sequence of Neurospora crassa is composed of a region of 5301 base pairs that has little similarity to the sequence present at the mating-type locus in an a mating-type strain. However, the sequences flanking the mating-type locus in the A haploid and a haploid genome are essentially identical. The region of the A mating-type sequence required for expression of the heterokaryon incompatibility and sexual functions has been localized to a single open reading frame (ORF) encoding a polypeptide of 288 amino acids. Sequence analysis of sterile, heterokaryon-compatible mutants reveals frameshift mutations in this same ORF. The putative 288-amino acid product has a region of similarity to the MAT alpha 1 polypeptide of Saccharomyces cerevisiae.

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References

    1. Cell. 1981 Nov;27(1 Pt 2):15-23 - PubMed
    1. Nature. 1981 Jan 22;289(5795):244-50 - PubMed
    1. Genes Dev. 1989 Jul;3(7):936-45 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. Bioessays. 1990 Feb;12(2):53-9 - PubMed

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