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. 2010 Oct 12:1:134.
doi: 10.3389/fpsyt.2010.00134. eCollection 2010.

Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study

David Pincus  1 , Samet Kose, Ashley Arana, Kevin Johnson, Paul S Morgan, Jeffrey Borckardt, Tal Herbsman, Fran Hardaway, Mark S George, Jaak Panksepp, Ziad Nahas
Affiliations

Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study

David Pincus et al. Front Psychiatry. .

Abstract

Background: Oxytocin is a stress-attenuating and pro-social neuropeptide. To date, no study has looked at the effects of oxytocin in modulating brain activity in depressed individuals nor attempted to correlate this activity with attribution of mental activity in others.

Method: We enrolled 10 unmedicated depressed adults and 10 matched healthy controls in a crossover, double blind placebo controlled fMRI 40 i.u. intra-nasal oxytocin study (20 i.u. per nostril). Each subject performed reading the mind in the eyes task (RMET) before and after inhalation of oxytocin or placebo control for a total of 80 scans.

Results: Before oxytocin administration, RMET engaged the medial and lateral prefrontal cortex, amygdala, insula and associative areas. Depressed subjects showed increased anterior ventral activation for the RMET minus gender identification contrast whereas matched controls showed increased dorsal and frontal activity. Compared to placebo, oxytocin in depressed subjects showed increased activity in the superior middle frontal gyrus and insula, while controls exhibited more activity in ventral regions. Oxytocin also led to inverse effects in reaction times on attribution task between groups, with controls getting faster and depressed individuals slower to respond.

Conclusion: Depression is associated with increased paralimbic activity during emotional mental attribution of others, appearing to be distinctly modulated by oxytocin when compared to healthy controls. Further studies are needed to explore long-term exposure to pro-social neuropeptides on mood in depressed populations and assess their clinical relevance.

Keywords: depression; fMRI; mentalization; oxytocin; theory of mind.

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Figures

Figure 1
Figure 1
Reaction time slope changes with intra-nasal oxytocin in healthy matched controls (blue) and depressed subjects (red) across RMET, gender attribution and motor cued response.
Figure 2
Figure 2
Baseline RMET minus Gender Attribution: Predominant ventral activations in unmedicated depressed subjects at baseline (red) compared to superior frontal and temporal activations in healthy matched controls (blue).
Figure 3
Figure 3
Baseline (green) and added activations with oxytocin compared to placebo (red) in unmedicated depressed subjects during RMET.
Figure 4
Figure 4
Baseline (green) and added activations with oxytocin compared to placebo (red) in healthy matched controls during RMET.
See this image and copyright information in PMC

References

    1. Anisman H. (1984). “Vulnerability to depression: contribution of stress,” in Neurobiology of Mood Disorders edsR. M. Post R. M., Ballenger J. C.(Baltimore: Williams and Wilkins; ), 407–431
    1. Baron-Cohen S., Ring H., Chitnis X., Wheelwright S., Gregory L., Williams S., Brammer M., Bullmore E. (2006). fMRI of parents of children with Asperger syndrome: a pilot study. Brain Cogn. 61, 122–13010.1016/j.bandc.2005.12.011 - DOI - PubMed
    1. Baron-Cohen S., Wheelwright S., Hill J., Raste Y., Plumb I. (2001). The “Reading the Mind in the Eyes” test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J. Child. Psychol. Psychiatry 42, 241–25110.1111/1469-7610.00715 - DOI - PubMed
    1. Bell C. (2006). Plasma oxytocin levels in depression and their correlation with the temperament dimension of reward dependence. J. Psychopharmacol. 20, 656–66010.1177/0269881106060512 - DOI - PubMed
    1. Burbach J. P., Schoots O., Hernando F. (1998). Biochemistry of vasopressin fragments. Prog. Brain Res. 119, 127–13610.1016/S0079-6123(08)61566-6 - DOI - PubMed