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. 2011 Feb 24:2011:701603.
doi: 10.4061/2011/701603.

Treatment of severe metastatic calcification and calciphylaxis in dialysis patients

Saurabh K Goel  1 , Keith Bellovich, Peter A McCullough
Affiliations

Treatment of severe metastatic calcification and calciphylaxis in dialysis patients

Saurabh K Goel et al. Int J Nephrol. .

Abstract

Metastatic calcification is a frequent complication encountered in patients undergoing maintenance dialysis and has a complex pathogenesis. It is often difficult to treat and is associated with high morbidity and mortality. Early recognition and prompt initiation of treatment is vital. Local wound care and aggressive metabolic control remain the cornerstones of the therapy. Various novel treatment strategies including sodium thiosulfate and hyperbaric oxygen therapy have been utilized and reviewed in this paper. The response rate to treatment is poor and prevention is the best approach.

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Figures

Figure 1
Figure 1
A large, necrotic, nonhealing ulceration on the abdomen of a patient with end stage renal disease, typical of a calciphylactic lesion.
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