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. 2011 Feb 22:2011:709061.
doi: 10.4061/2011/709061.

May "mitochondrial eve" and mitochondrial haplogroups play a role in neurodegeneration and Alzheimer's disease?

Elena Caldarazzo Ienco  1 , Costanza Simoncini, Daniele Orsucci, Loredana Petrucci, Massimiliano Filosto, Michelangelo Mancuso, Gabriele Siciliano
Affiliations

May "mitochondrial eve" and mitochondrial haplogroups play a role in neurodegeneration and Alzheimer's disease?

Elena Caldarazzo Ienco et al. Int J Alzheimers Dis. .

Abstract

Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Multiple evidences suggest that mitochondria may be crucial in ageing-related neurodegenerative diseases. Moreover, mitochondrial haplogroups have been linked to multiple area of medicine, from normal ageing to diseases, including neurodegeneration. Polymorphisms within the mitochondrial genome might lead to impaired energy generation and to increased amount of reactive oxygen species, having either susceptibility or protective role in several diseases. Here, we highlight the role of the mitochondrial haplogroups in the pathogenetic cascade leading to diseases, with special attention to Alzheimer's disease.

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Figures

Figure 1
Figure 1
MtDNA haplogroup migration patterns. The map shows the migration patterns of the main mtDNA haplogroups.
See this image and copyright information in PMC

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