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. 2010 Feb 9;3(1):8-18.
doi: 10.6030/1939-067x-3.1.8.

Clinical trial structures

Scott R Evans  1
Affiliations

Clinical trial structures

Scott R Evans. J Exp Stroke Transl Med. .

Abstract

Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. The selection of a clinical trial design structure requires logic and creativity. Common structural designs are discussed.

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Figures

Figure 1
Figure 1
ACTG A5252 crossover design schema
Figure 2
Figure 2
Noninferiority design. P1 is the efficacy of the new therapy. P2 is the efficacy of the control group. −M is the noninferiority margin.
See this image and copyright information in PMC

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