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. 2011 Nov;38(8):5459-64.
doi: 10.1007/s11033-011-0702-9. Epub 2011 Mar 20.

Influence of sCD40L on gastric cancer cell lines

Rui Li  1 , Wei-Chang Chen, Xue-Qin Pang, Wen-Yan Tian, Xue-Guang Zhang
Affiliations

Influence of sCD40L on gastric cancer cell lines

Rui Li et al. Mol Biol Rep. 2011 Nov.

Abstract

The CD40 signaling pathway plays a key role in tumor cell proliferation, differentiation, and apoptosis. Gastric cancer usually possesses a higher level of CD40 expression than normal tissue. We evaluated inhibition of soluble CD40 ligand (sCD40L) in apoptosis induction of gastric cancer cells. Gastric cancer cells (AGS and BGC-823) were incubated with sCD40L. Cell viability and cell cycle were determined by methyl-tetrazolium (MTT) assay and flow cytometry, respectively. The results showed that sCD40L hindered cell growth, arrested cells at G0/G1 phase and induced apoptosis. In conclusion, sCD40L suppress growth of gastric cancer cells through apoptosis induction and cell cycle quiescence. This work will provided a new approach to gene therapy of gastric cancer.

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