Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jul;85(2):165-70.
doi: 10.1007/BF00193190.

Epidemiological and linkage studies on Huntington's disease in Italy

M Frontali  1 , P Malaspina, C Rossi, A G Jacopini, G Vivona, M S Pergola, A Palena, A Novelletto
Affiliations

Epidemiological and linkage studies on Huntington's disease in Italy

M Frontali et al. Hum Genet. 1990 Jul.

Abstract

The results of an epidemiological survey on Huntington's disease in the Lazio Region, Central Italy, and of linkage studies in a subset of families are reported. From a total of 99 ascertained families and 491 patients, a prevalence of 25.6 X 10(-6) was obtained, with distributions of age at onset and age at death similar to those described in the literature. No relationship with the sex of the transmitting parent was observed. Analysis of 10 chromosome 4 restriction fragment length polymorphisms in 11 families showed consistent linkage between the genetic loci D4S10, D4S43 and D4S95, and the disease. A recombination rate of 0.08 for D4S10 markers was obtained in this sample. Allelic frequencies of DNA markers in the general population are also reported.

PubMed Disclaimer

References

    1. Ann Hum Genet. 1981 Oct;45(Pt 4):387-96 - PubMed
    1. Am J Hum Genet. 1974 Sep;26(5):588-97 - PubMed
    1. Nucleic Acids Res. 1987 Nov 11;15(21):9100 - PubMed
    1. Nature. 1983 Nov 17-23;306(5940):234-8 - PubMed
    1. Am J Hum Genet. 1988 Feb;42(2):335-44 - PubMed

Publication types

LinkOut - more resources