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Review
. 2011 Jul;17(7):372-9.
doi: 10.1016/j.molmed.2011.02.003. Epub 2011 Mar 21.

Balancing histone methylation activities in psychiatric disorders

Cyril Jayakumar Peter  1 , Schahram Akbarian
Affiliations
Review

Balancing histone methylation activities in psychiatric disorders

Cyril Jayakumar Peter et al. Trends Mol Med. 2011 Jul.

Abstract

Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and demethylases in the neurobiology of emotion and cognition. Here, we review the role of histone lysine methylation and transcriptional regulation in normal and diseased neurodevelopment and discuss various methyltransferases and demethylases as potential therapeutic targets in the treatment of neuropsychiatric disease.

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Figures

Figure 1
Figure 1
Regulation of histone (K) methylation. (A) Listings of residue-specific KMTs and KDMs for H3K4/9/27/36/79 and H4K20. The majority of KMT and KDM are highly specific for a single histone residue, while a few enzymes target multiple residues, as indicated. Red marked KMT/KDM are implicated in neurodevelopment or psychiatric disease as discussed in main text. The non-catalytic JARID2 regulates activity and function of related KMTs. (B) Simplified scheme for selected mono- and trimethylated histone lysine markings implicated in transcriptional regulation, silencing and enhancer functions.
See this image and copyright information in PMC

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