Are we ready to demystify age in glioblastoma? Or does older age matter in glioblastoma?

Editorial

Michael Weller et al. Neuro Oncol. 2011 Apr.

. 2011 Apr;13(4):365-6.

doi: 10.1093/neuonc/nor019.

No abstract available

Comment on

Aggressive treatment is appropriate for glioblastoma multiforme patients 70 years old or older: a retrospective review of 206 cases.
Scott JG, Suh JH, Elson P, Barnett GH, Vogelbaum MA, Peereboom DM, Stevens GH, Elinzano H, Chao ST. Scott JG, et al. Neuro Oncol. 2011 Apr;13(4):428-36. doi: 10.1093/neuonc/nor005. Epub 2011 Mar 1. Neuro Oncol. 2011. PMID: 21363881 Free PMC article.

1. Scott JG, Suh JH, Elson P, et al. Aggressive treatment is appropriate for glioblastoma multiforme patients 70 years old or older: a retrospective review of 206 cases. Neuro-Oncology. 2011;13:428–436. - PMC - PubMed
1. Hartmann C, Hentschel B, Wick W, et al. Patients with IDH1 wild type anaplastic astroctytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol. 2010;120:707–718. - PubMed
1. Gerstner ER, Yip S, Wang DL, et al. MGMT methylation is a prognostic biomarker in elderly patients with newly diagnosed glioblastoma. Neurology. 2009;73:1509–1510. - PMC - PubMed
1. Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466. - PubMed
1. Keime-Guibert F, Chinot O, Taillandier L, et al. Radiotherapy for glioblastoma in the elderly. N Engl. J. Med. 2007;356:1527–1535. - PubMed