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. 2011 Jan;36(1):35-9.
doi: 10.4103/0971-6203.75470.

To study tumor motion and planning target volume margins using four dimensional computed tomography for cancer of the thorax and abdomen regions

Sudesh Deshpande  1
Affiliations

To study tumor motion and planning target volume margins using four dimensional computed tomography for cancer of the thorax and abdomen regions

Sudesh Deshpande. J Med Phys. 2011 Jan.

Abstract

In this study, four dimensional computed tomography (4DCT) scanning was performed during free breathing on a 16-slice Positron emission tomography PET /computed tomography (CT) for abdomen and thoracic patients. Images were sorted into 10 phases based on the temporal correlation between surface motion and data acquisition with an Advantage Workstation. Gross tumor volume gross tumor volume (GTV) s were manually contoured on all 10 phases of the 4DCT scan. GTVs in the multiple CT phases were called GTV4D. GTV4D plus an isotropic margin of 1.0 cm was called CTV4D. Two sets of planning target volume (PTV) 4D (PTV4D) were derived from the CTV4D, i.e. PTV4D(2cm) = CTV4D plus 1 cm setup margin (SM) and 1 cm internal margin (IM) and PTV4D(1.5cm) = CTV4D plus 1 cm SM and 0.5cm IM. PTV3D was derived from a CTV3D of the helical CT scan plus conventional margins of 2 cm. PTV(gated) was generated only selecting three CT phases, with a total margin of 1.5 cm. All four volumes were compared. To quantify the extent of the motion, we selected the two phases where the tumor exhibited the greatest range of motion. We also studied the effect of different PTV volumes on dose to the surrounding critical structures. Volume of CTV4D was greater than that of CTV3D. We found, on an average, a reduction of 14% volume of PTV4D(1.5cm) as compared with PTV3D and reduction of 10% volume of PTV(gated) as compared with PTV4D(1.5cm). We found that 2 cm of margin was inadequate if true motion of tumor was not known. We observed greater sparing of critical structures for PTVs drawn taking into account the tumor motion.

Keywords: four dimensional computed tomography; tumor motion and PTV margin reduction for thoracic and abdomen tumor.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Respiratory cycle If the respiratory cycle is viewed as a waveform, then a phase is a position within the breathing cycle where 0% = peak inspiration, 50% = peak expiration and 100% = peak inspiration
Figure 2
Figure 2
Overlapping of PTV volumes Overlapping of PTV3D and PTV4D1.5cm in the abdomen region. Nonoverlapping region is in the superior to inferior direction
See this image and copyright information in PMC

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