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. 2011 Jan;3(1):118-27.
doi: 10.4103/0975-7406.76489.

Acute-phase proteins: As diagnostic tool

Sachin Jain  1 , Vidhi Gautam, Sania Naseem
Affiliations

Acute-phase proteins: As diagnostic tool

Sachin Jain et al. J Pharm Bioallied Sci. 2011 Jan.

Abstract

The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein depletion combining to minimize tissue damage while enhancing the repair process. The mechanism for stimulation of hepatic production of acute-phase proteins is by proinflammatory cytokines. The functions of positive acute-phase proteins (APP) are regarded as important in optimization and trapping of microorganism and their products, in activating the complement system, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free hemoglobin and radicals, and in modulating the host's immune response. APP can be used as diagnostic tool in many diseases like bovine respiratory syncytial virus, prostate cancer, bronchopneumonia, multiple myeloma, mastitis, Streptococcus suis infection, starvation, or lymphatic neoplasia. Thus, acute-phase proteins may provide an alternative means of monitoring animal health.

Keywords: Acute-phase proteins; C-reactive protein; diagnosis; haptoglobin; serum amyloid A.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Synthesis of acute phase proteins
See this image and copyright information in PMC

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