Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jul;9(4):130-6.
doi: 10.1007/BF02898091.

Evidence in favour of lifestyle intervention for cancer prevention with special reference to colorectal cancer

Kaoru Hirose  1 , Kazuo Tajima
Affiliations

Evidence in favour of lifestyle intervention for cancer prevention with special reference to colorectal cancer

Kaoru Hirose et al. Environ Health Prev Med. 2004 Jul.

Abstract

Randomized controlled trials are recognized as having the strongest type of study design for generating evidence on prevention of disease. They are, however, the most labor- and time-intensive and costly to conduct. Intervention studies on the recurrence of colorectal adenomas might serve as a model with relevance to the etiology of not only large bowel cancer but also other sites of neoplastic development. The results of intervention studies assessing the effect of calcium, antioxidants and fiber on the recurrence of colorectal adenomas have been conflicting, showing a beneficial effect in some cases but not others. There are methodological issues in intervention trials for colorectal cancer, regarding study subjects, end point, dose, interaction, duration and timing, and compliance, for example. Although relatively few trials have been conducted to investigate the effects of an explicit dietary change on the recurrence of adenoma, results obtained so far have demonstrated that modifying the lifestyle may reduce the risk of chronic diseases including cancer. Furthermore, recent progress in molecular epidemiology has allowed clarification of many of the molecular mechanisms underlying susceptibility. Eventually, it may be possible to target intervention programs to genetically susceptible individuals, including molecular targeting, for the prevention of cancer.

Keywords: cancer prevention; intervention.

PubMed Disclaimer

References

    1. None
    2. Cook JW, Hazelwood GA. Conversion of a bile acid into a hydrocarbon derived from 1,2-benzanthracene. Chem. Ind. Rev. 1933; 11: 758–759.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '6587152', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/6587152/'}]}
    2. Newmark HL, Wargovich MJ, Bruce WR. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J. Natl. Cancer Inst. 1984; 72: 1323–1325. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/bjs.1800740635', 'is_inner': False, 'url': 'https://doi.org/10.1002/bjs.1800740635'}, {'type': 'PubMed', 'value': '3607416', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/3607416/'}]}
    2. Appleton GV, Davies PW, Bristol JB, Williamson RC. Inhibition of intestinal carcinogenesis by dietary supplementaion with calcium. Br. J. Surg. 1987; 74: 523–525. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1093/carcin/9.1.187', 'is_inner': False, 'url': 'https://doi.org/10.1093/carcin/9.1.187'}, {'type': 'PubMed', 'value': '2826033', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/2826033/'}]}
    2. Pence BC, Budding F. Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. Carcinogenesis 1988; 9: 187–190. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1079/BJN19900050', 'is_inner': False, 'url': 'https://doi.org/10.1079/bjn19900050'}, {'type': 'PubMed', 'value': '2223749', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/2223749/'}]}
    2. Behling AR, Kaup SM, Choquette LL, Greger JL. Lipid absorption and intestinal tumor incidence in rats fed varying levels of calcium and butterfat. Br. J. Nutr. 1990; 64: 505–513. - PubMed