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. 2002 Jan;6(4):203-9.
doi: 10.1007/BF02897971.

Omega-3 fatty acids and cardiovascular disease: The epidemiological evidence

Artemis P Simopoulos  1
Affiliations

Omega-3 fatty acids and cardiovascular disease: The epidemiological evidence

Artemis P Simopoulos. Environ Health Prev Med. 2002 Jan.

Abstract

Epidemiological studies in the last 40 years suggest that omega-3 fatty acids derived from fish and fish oil decrease the risk of coronary heart disease, hypertension and stroke, and their complications. The beneficial effects of omega-3 fatty acids include effects on lipids, blood pressure, cardiac and vascular function, eicosanoids, coagulation, and immunological responses. However, not all population studies have shown that omega-3 fatty acids are associated with reduced rates of coronary mortality. Such studies suffer either from small numbers of subjects or the population already had a high intake of fish. When comparing the highest intake of fish to that of the lowest fish intake, the beneficial effects of omega-3 fatty acids have been shown. In population-based case-control studies, the patients consuming modest amounts of fish, the equivalent of one fatty fish meal per week, had a significant lower risk of primary cardiac arrest compared with those who did not eat fish at all. In case-control studies, the intake of eicosapentaenoic acid and docosahexaenoic acid as reflected in adipose tissue content is inversely associated with risk of myocardial infarction.

Keywords: coronary heart disease; docosahexaenoic acid; eicosapentaenoic acid; hypertension; omega-3 fatty acids.

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