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. 2003 Jan;7(6):239-45.
doi: 10.1007/BF02908882.

Pleiotrophic actions of erythropoietin

Laurie Feldman  1 , Arthur J Sytkowski
Affiliations

Pleiotrophic actions of erythropoietin

Laurie Feldman et al. Environ Health Prev Med. 2003 Jan.

Abstract

Erythropoietin is the prime regulator of red blood cell production. However, recent evidence suggests that the hormone has multiple effects outside the hematopoietic system. Functional receptors have been identified on a wide variety of normal and malignant cell types, and numerous biologic effects of the hormone on these cells have been observed both in vitro and in vivo. These findings are causing a reassessment of the understanding of erythropoietin physiology. Moreover, there are important implications for the use of recombinant erythropoietin in the clinical setting.

Keywords: angiogenesis; brain; cancer; gut; reproductive system.

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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC6763035', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC6763035/'}, {'type': 'PubMed', 'value': '11739582', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11739582/'}]}
    2. Shingo T, Sorokan ST, Shimazaki R, Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian neural stem cells. J. Neuroscience 2001; 21(24): 9733–9743. - PMC - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11154762', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11154762/'}]}
    2. Dame C, Bartmann P, Wolber E, Fahnenstich H, Hofmann D, Fandry J. Erythropoietin gene expression in different areas of the developing human central nervous system. Brain Research-Developmental Brain Research 2000; 125(1–2): 60–74. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1007/s100249900103', 'is_inner': False, 'url': 'https://doi.org/10.1007/s100249900103'}, {'type': 'PubMed', 'value': '9949221', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/9949221/'}]}
    2. Juul SE, Yachnis AT, Rojiani AM, Christensen RD. Immunohistochemical localization of Erythropoietin and its receptor in the developing human brain. Pediatric and Developmental Pathology 1999; 2(2): 148–158. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11395856', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11395856/'}]}
    2. Carami A, Brines ML, Ghezzi P, Cerami CJ. Effects of epoetin alpha on the central nervous system. Seminars in Oncology 2001, 28 (2 Suppl 8): 66–70. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC27058', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC27058/'}, {'type': 'PubMed', 'value': '10984541', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10984541/'}]}
    2. Brines ML, Ghezzi P, Keenan S, Agnello D, deLanerolle NC, Cerami C, Itri LM, Cerami A. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. USA 2001; 97(19): 10527–10531. - PMC - PubMed