Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jan;7(6):292-4.
doi: 10.1007/BF02908889.

Experimental study on fibrogenic effect of fur dust on rat lung

Jie Chen  1 , Yongli Cui, Yingchun Sun, Jiezhi Lou, Zhenlin Liu
Affiliations

Experimental study on fibrogenic effect of fur dust on rat lung

Jie Chen et al. Environ Health Prev Med. 2003 Jan.

Abstract

Objective: The fibrogenicity of fur dust was studied in rat lung tissues.

Methods: Intratracheal instillation of fur dust, morphologic examination of lungs and analysis of collagen content were performed in Wistar rats.

Results: Morphologic examination revealed that the earliest changes consisted of alveolar edema, increased numbers of intraalveolar macrophages, and marked thickening of interalveolar septa with mixed cellular infiltrate. After sixth months, there was moderate thickening of the alveolar walls and the peribronchioli. After 12 months, interstitial positive fibrosis of the alveolar wall and the peribronchioli were weakly seen. In the carding dust group (silica content 17.6%), interstitial nodules were observed composed of fibroblasts, reticular fibers, and collagen fibers. Electron microscopic examination also showed that alveolar walls became thickened and collagen fiber bundles were seen around bronchioles and small vessels in the carding groups after 12 months. At all stages of analysis, the collagen content in lungs of the fur dust groups was significantly higher than that of the control group.

Conclusions: Our study suggested that fur dust might induce weak interstitial fibrosis in the lung.

PubMed Disclaimer

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1093/occmed/33.1.36', 'is_inner': False, 'url': 'https://doi.org/10.1093/occmed/33.1.36'}, {'type': 'PubMed', 'value': '6687481', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/6687481/'}]}
    2. Allardice JT, Clarke EC, Jones RD. A study of the prevalence of epitaxis and respiratory symptoms in carpet backwinders. J. Soc. Occup. Med. 1983; 33: 36-41. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '989708', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/989708/'}]}
    2. Zuskin E, Valic F, Bouhuys A. Effect of wool dust on respiratory function. Am. Rev. Resp. Dis. 1976; 114(4): 705-709. - PubMed
    1. None
    2. Meng D, Chen J, Lou J, Guo X. Study on lung functions after acute exposure to fur dust. Ind. Health Occup. Dis. 1994; 20(4): 214-217 (in Chinese).
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/ajim.4700280313', 'is_inner': False, 'url': 'https://doi.org/10.1002/ajim.4700280313'}, {'type': 'PubMed', 'value': '7485197', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/7485197/'}]}
    2. Zuskin E, Kanceljak B, Mustajbegovic J, Godnic-Cvar J, Schachter EN. Immunological reactions and respiratory function in wool textile workers. Am. J. Ind. Med. 1995; 28(3): 445-456. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '7645578', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/7645578/'}]}
    2. Zuskin E, Mustajbegovic J, Schachter EN, Kanceljak B, Godnic-Cvar J, Sitar-Srebocan V. Respiratory symptoms and lung function in wool textile workers. Am. J. Ind. Med. 1995; 27(6): 845-857 - PubMed