Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Oct;3(3):168-74.
doi: 10.1007/BF02931709.

Risk factors for the incidence of aortic stiffness by serial aortic pulse wave velocity measurement in middle-aged Japanese men

N Nakanishi  1 , K Suzuki, H Kawashimo, K Nakamura, K Tatara
Affiliations

Risk factors for the incidence of aortic stiffness by serial aortic pulse wave velocity measurement in middle-aged Japanese men

N Nakanishi et al. Environ Health Prev Med. 1998 Oct.

Abstract

To examine the risk factors related to the incidence of aortic stiffness, 1,045 Japanese men aged 40 to 54 years with aortic pulse wave velocity (PWV) of less than 8.0 m/sec were followed up for seven years with annual examinations, with an average period of observation of 6.3 years with standard deviation of 1.56 years. Subjects who showed 8.0 m/sec and over of PWV during follow-up surveys were defined as incidental cases of aortic stiffness. Kaplan-Meier analysis showed that die incidence of aortic stiffness increased significantly with increases in age, body mass index, and total cholesterol and low-density lipoprotein (LDL) cholesterol levels. The incidence of aortic stiffness was significantly higher among those who had or currently smoked than among those who never smoked. From multivariate analysis using Cox proportional hazards model, the incidence of aortic stiffness showed a significant dose-response relationship for age, PWV, total cholesterol and LDL cholesterol levels and smoking habits. These results indicate that increased levels of total cholesterol and LDL cholesterol and smoking habits may constitute contributing factors for the development of aortic stiffness in middle-aged Japanese men.

Keywords: aortic stiffness; follow-up study; pulse wave velocity; risk factors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/0002-9149(87)90908-8', 'is_inner': False, 'url': 'https://doi.org/10.1016/0002-9149(87)90908-8'}, {'type': 'PubMed', 'value': '3591683', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/3591683/'}]}
    2. Stefanadis CI, Wooley CF, Bush CA, Kolobash AJ, Boudoulas HK. Aortic distensibility abnormalities in coronary artery disease. Am J Cardiol 1987:59:1300–4. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '2610739', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/2610739/'}]}
    2. Hirai T, Sasayama S, Kawasaki T, Yagi S. Stiffness of systemic arteries in patients with myocardial infarction: a noninvasive method to predict severity of coronary atherosclerosis. Circulation 1989:80:78–86. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '2282929', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/2282929/'}]}
    2. Stefanadis C, Stratos C, Boudoulas H, Kourouklis C, ToutouzasP. Distensibility of the ascending aorta: comparison of invasive and noninvasive techniques in healthy men and women with coronary artery disease. Eur Heart J 1990;11:990–6. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/0140-6736(91)90415-L', 'is_inner': False, 'url': 'https://doi.org/10.1016/0140-6736(91)90415-l'}, {'type': 'PubMed', 'value': '1677109', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/1677109/'}]}
    2. Dart AM, Lacombe F, Yeoh JK, et al. Aortic distensibility in patients with isolated hypercholesterolaemia, coronary heart disease, or cardiac transplant. Lancet 1991;338:270–3. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1093/cvr/21.9.678', 'is_inner': False, 'url': 'https://doi.org/10.1093/cvr/21.9.678'}, {'type': 'PubMed', 'value': '3328650', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/3328650/'}]}
    2. Kawasaki T, Sasayama S, Yagi S, Asakawa T, Hirai T. Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries. Cardiovasc Res 1987;21:678–87. - PubMed