Methods Guide for Effectiveness and Comparative Effectiveness Reviews [Internet]
- PMID: 21433403
- Bookshelf ID: NBK47095
Methods Guide for Effectiveness and Comparative Effectiveness Reviews [Internet]
Excerpt
Comparative Effectiveness Reviews are systematic reviews of existing research on the effectiveness, comparative effectiveness, and harms of different health care interventions. They provide syntheses of relevant evidence to inform real-world health care decisions for patients, providers, and policymakers. Strong methodologic approaches to systematic review improve the transparency, consistency, and scientific rigor of these reports. Through a collaborative effort of the Effective Health Care (EHC) Program, the Agency for Healthcare Research and Quality (AHRQ), the EHC Program Scientific Resource Center, and the AHRQ Evidence-based Practice Centers have developed a Methods Guide for Comparative Effectiveness Reviews. This Guide presents issues key to the development of Comparative Effectiveness Reviews and describes recommended approaches for addressing difficult, frequently encountered methodological issues.
The Methods Guide for Comparative Effectiveness Reviews is a living document, and will be updated as further empiric evidence develops and our understanding of better methods improves. Comments and suggestions on the Methods Guide for Comparative Effectiveness Reviews and the Effective Health Care Program can be made at
Sections
- Comparing Medical Interventions: AHRQ and the Effective Health Care Program
- Principles in Developing and Applying Guidance
- Identifying, Selecting, and Refining Topics
- Developing and Selecting Topic Nominations for Systematic Reviews
- The Refinement of Topics for Systematic Reviews: Lessons and Recommendations From the Effective Health Care Program
- Finding Evidence for Comparing Medical Interventions
- Finding Grey Literature Evidence and Assessing for Outcome and Analysis Reporting Biases When Comparing Medical Interventions: AHRQ and the Effective Health Care Program
- Avoiding Bias in Selecting Studies
- Selecting Observational Studies for Comparing Medical Interventions
- Assessing the Risk of Bias in Systematic Reviews of Health Care Interventions
- Assessing the Applicability of Studies When Comparing Medical Interventions
- Prioritization and Selection of Harms for Inclusion in Systematic Reviews
- Assessing Harms When Comparing Medical Interventions
- Quantitative Synthesis—An Update
- Grading the Strength of a Body of Evidence When Assessing Health Care Interventions for the Effective Health Care Program of the Agency for Healthcare Research and Quality: An Update
- Using Existing Systematic Reviews To Replace De Novo Processes in Conducting Comparative Effectiveness Reviews
- Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies
- Updating Comparative Effectiveness Reviews: Current Efforts in AHRQ’s Effective Health Care Program
- Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment
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