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Comment
. 2011 Mar 25;34(3):283-5.
doi: 10.1016/j.immuni.2011.03.011.

Caspase-8: clipping off RIG-I signaling

Susanne Roth  1 , Jürgen Ruland
Affiliations
Free article
Comment

Caspase-8: clipping off RIG-I signaling

Susanne Roth et al. Immunity. .
Free article

Abstract

Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.

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