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. 2011 May 12;29(21):3811-7.
doi: 10.1016/j.vaccine.2011.03.013. Epub 2011 Mar 23.

Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Bruce Y Lee  1 , Tina-Marie Assi, Korngamon Rookkapan, Diana L Connor, Jayant Rajgopal, Vorasith Sornsrivichai, Shawn T Brown, Joel S Welling, Bryan A Norman, Sheng-I Chen, Rachel R Bailey, Ann E Wiringa, Angela R Wateska, Anirban Jana, Willem G Van Panhuis, Donald S Burke
Affiliations

Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Bruce Y Lee et al. Vaccine. .

Abstract

Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.

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Figures

Figure 1
Figure 1
Thailand vaccine supply chain network
Figure 2
Figure 2
Frequency Distribution of Open Vial Waste from the Ten-dose Measles Vaccine by Administration Locations across a Year
Figure 3
Figure 3
Frequency Distribution of Waste Disposal Costs for Ten-dose Measles, Single-dose Measles, and Single-dose MMR Vaccines by Vaccine Administering Site
See this image and copyright information in PMC

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