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Review
. 1990 Jul 25;1018(2-3):203-5.
doi: 10.1016/0005-2728(90)90249-4.

A plasmid-encoded anion-translocating ATPase

B P Rosen  1 , C M Hsu, C E Karkaria, P Kaur, J B Owolabi, L S Tisa
Affiliations
Free article
Review

A plasmid-encoded anion-translocating ATPase

B P Rosen et al. Biochim Biophys Acta. .
Free article

Abstract

An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.

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