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. 2011 May;14(5):545-7.
doi: 10.1038/nn.2785. Epub 2011 Mar 27.

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

Jihoon Jo  1 , Daniel J Whitcomb, Kimberly Moore Olsen, Talitha L Kerrigan, Shih-Ching Lo, Gilles Bru-Mercier, Bryony Dickinson, Sarah Scullion, Morgan Sheng, Graham Collingridge, Kwangwook Cho
Affiliations

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

Jihoon Jo et al. Nat Neurosci. 2011 May.

Abstract

Amyloid-β(1-42) (Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice.

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