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Comment
. 2011 Mar 29;43(4):287-8.
doi: 10.1038/ng0411-287.

Next-generation association studies for complex traits

Eleftheria Zeggini  1
Affiliations
Comment

Next-generation association studies for complex traits

Eleftheria Zeggini. Nat Genet. .

Abstract

A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.

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Figures

Figure 1
Figure 1
Overview of the steps involved in a next-generation complex trait association study.
See this image and copyright information in PMC

Comment on

  • A rare variant in MYH6 is associated with high risk of sick sinus syndrome.
    Holm H, Gudbjartsson DF, Sulem P, Masson G, Helgadottir HT, Zanon C, Magnusson OT, Helgason A, Saemundsdottir J, Gylfason A, Stefansdottir H, Gretarsdottir S, Matthiasson SE, Thorgeirsson GM, Jonasdottir A, Sigurdsson A, Stefansson H, Werge T, Rafnar T, Kiemeney LA, Parvez B, Muhammad R, Roden DM, Darbar D, Thorleifsson G, Walters GB, Kong A, Thorsteinsdottir U, Arnar DO, Stefansson K. Holm H, et al. Nat Genet. 2011 Mar 6;43(4):316-20. doi: 10.1038/ng.781. Nat Genet. 2011. PMID: 21378987 Free PMC article.

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