DNMT3A mutations in acute myeloid leukemia
- PMID: 21445072
- DOI: 10.1038/ng0411-289
DNMT3A mutations in acute myeloid leukemia
Abstract
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
Comment on
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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.Nat Genet. 2011 Mar 13;43(4):309-15. doi: 10.1038/ng.788. Nat Genet. 2011. PMID: 21399634
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