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Comment
. 2011 Mar 29;43(4):289-90.
doi: 10.1038/ng0411-289.

DNMT3A mutations in acute myeloid leukemia

Mrinal Y Shah  1 , Jonathan D Licht
Affiliations
Comment

DNMT3A mutations in acute myeloid leukemia

Mrinal Y Shah et al. Nat Genet. .

Abstract

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

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