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. 2011 Mar;9(3):e1001037.
doi: 10.1371/journal.pbio.1001037. Epub 2011 Mar 22.

Regarding the amazing choreography of clathrin coats

Linton M Traub  1
Affiliations

Regarding the amazing choreography of clathrin coats

Linton M Traub. PLoS Biol. 2011 Mar.
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Clathrin-mediated endocytosis.
(A) A schematic bird's-eye view of a mammalian cell showing randomly scattered clathrin-coated structures (green) positioned on the adherent cell surface. (B) Confocal immunofluorescence image of the adherent surface of HeLa cells stained with an antibody against the AP-2 adaptor protein showing coexistence of diffraction-limited spots (arrowheads) and large clathrin patches (arrows). (C) High-resolution electron micrograph of the adherent surface of a cultured fibroblast (courtesy of John Heuser) showing areas of flat clathrin lattice (pseudocolored in green). (D) Schematic depiction of the process of clathrin-coated vesicle assembly at the various types of bud site analyzed by Taylor et al. .
Figure 2
Figure 2. The vertebrate endocytic clathrin-coat protein interaction network.
Hub-and-spoke depiction of a selected subset of the known proteins participating in clathrin-mediated endocytosis. Established interactions are indicated by the spokes. Modules are colored as in Taylor et al. and the proteins they analyzed are shown in larger font. Note that not all of the temporally defined modules are shown here. The symbols with black centers indicate proteins that bind to phosphatidylinositol 4,5-bisphosphate, a lipid marker of the plasma membrane. How can clathrin and AP-2 each bind to so many partners (at once)? The functional clathrin molecule has at least 15 physically separate interaction surfaces while each AP-2 complex has over ten.
See this image and copyright information in PMC

References

    1. Schmid E. M, McMahon H. T. Integrating molecular and network biology to decode endocytosis. Nature. 2007;448:883–888. - PubMed
    1. Conner S. D, Schmid S. L. Regulated portals of entry into the cell. Nature. 2003;422:37–44. - PubMed
    1. Iwasa J. H. Animating the model figure. Trends Cell Biol. 2010;20:699–704. - PubMed
    1. Mitsunari T, Nakatsu F, Shioda N, Love P. E, Grinberg A, et al. Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol. 2005;25:9318–9323. - PMC - PubMed
    1. Traub L. M. Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol. 2009;10:583–596. - PubMed