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Review
. 2011 Jul-Aug;29(4):418-35.
doi: 10.1016/j.biotechadv.2011.03.004. Epub 2011 Apr 5.

Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications

Shrikant A Survase  1 , Lalit D Kagliwal, Uday S Annapure, Rekha S Singhal
Affiliations
Review

Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications

Shrikant A Survase et al. Biotechnol Adv. 2011 Jul-Aug.

Abstract

In present times, the immunosuppressants have gained considerable importance in the world market. Cyclosporin A (CyA) is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal and antiparasitic properties. CyA is produced by various types of fermentation techniques using Tolypocladium inflatum. In the present review, we discuss the biosynthetic pathway, fermentative production, downstream processing and pharmacological activities of CyA.

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