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Clinical Trial
. 2011 Jun;26(6):724-8.
doi: 10.1177/0883073810390036. Epub 2011 Mar 29.

Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy

Courtney J Wusthoff  1 , Dennis J Dlugos, Ana Gutierrez-Colina, Anne Wang, Noah Cook, Maureen Donnelly, Robert Clancy, Nicholas S Abend
Affiliations
Clinical Trial

Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy

Courtney J Wusthoff et al. J Child Neurol. 2011 Jun.

Abstract

Electrographic seizures are common in neonates with hypoxic-ischemic encephalopathy, but detailed data are not available regarding seizure incidence during therapeutic hypothermia. The objective of this prospective study was to determine the incidence and timing of electrographic seizures in term neonates undergoing whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy as detected by conventional full-array electroencephalography for 72 hours of therapeutic hypothermia and 24 hours of normothermia. Clinical and electroencephalography data were collected from 26 consecutive neonates. Electroencephalograms were reviewed by 2 pediatric neurophysiologists. Electrographic seizures occurred in 17 of 26 (65%) patients. Seizures were entirely nonconvulsive in 8 of 17 (47%), status epilepticus occurred in 4 of 17 (23%), and seizure onset was in the first 48 hours in 13 of 17 (76%) patients. Electrographic seizures were common, were often nonconvulsive, and had onset over a broad range of times in the first days of life.

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Figures

Figure 1
Figure 1
Seizures and status epilepticus by subject over time.
See this image and copyright information in PMC

References

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