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. 2011;16(2):137-40.
doi: 10.3851/IMP1750.

Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule

Christopher B Hurt  1
Affiliations

Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule

Christopher B Hurt. Antivir Ther. 2011.

Abstract

Transmitted drug resistance (TDR), the primary acquisition of an HIV variant already resistant to antiretrovirals, affects approximately 15% of all new infections in the United States. Historically, from the time initial agents in the reverse transcriptase, protease and entry inhibitor classes were introduced, it took 3-5 years before the first case reports of TDR appeared. With the description of the first two cases of transmitted integrase stand-transfer inhibitor resistance, it is only a matter of time before the prevalence of TDR affecting this newest antiretroviral class reaches a level warranting baseline resistance testing for all patients entering care.

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Conflict of interest statement

Conflicts of interest: CBH has received grant support from Bristol-Myers Squibb and Merck.

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