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Case Reports
. 2011;3(1):40-2.
doi: 10.4274/jcrpe.v3i1.09. Epub 2011 Feb 23.

Eight-year follow-up of a girl with McCune-Albright syndrome

Zehra Aycan  1 , Aşan Önder, Semra Çetinkaya
Affiliations
Case Reports

Eight-year follow-up of a girl with McCune-Albright syndrome

Zehra Aycan et al. J Clin Res Pediatr Endocrinol. 2011.

Abstract

McCune-Albright syndrome (MAS) is characterized by the triad of fibrous dysplasia (FD), cafe-au-lait spots and precocious puberty (PP). We report a 14-year-old girl with MAS who has been followed-up for 8 years. She was referred for multiple fractures and vaginal bleeding at age 5.9 years. She had peripheral PP, FD, and osteoporosis and was diagnosed as MAS. The patient was treated with aromatase inhibitors and bisphosphonates. She had no menses during aromatase inhibitor treatment. Her growth rate and bone maturation were in normal ranges while on treatment. She had one new fracture on the seventh year of follow- up in spite of bisphosphonate treatment.

Keywords: McCune-Albright syndrome; aromatase inhibitor; bisphosphonate; follow-up.

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