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Review
. 2011 Oct;118(10):1453-60.
doi: 10.1007/s00702-011-0631-8. Epub 2011 Mar 30.

Pedunculopontine stimulation from primate to patient

Erlick A C Pereira  1 , Dipankar Nandi, Ned Jenkinson, John F Stein, Alexander L Green, Tipu Z Aziz
Affiliations
Review

Pedunculopontine stimulation from primate to patient

Erlick A C Pereira et al. J Neural Transm (Vienna). 2011 Oct.

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

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