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. 2011 May;55(5):798-802.
doi: 10.1002/mnfr.201100115. Epub 2011 Mar 24.

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Ute Boettler  1 , Nadine Volz, Gudrun Pahlke, Nicole Teller, Christine Kotyczka, Veronika Somoza, Herbert Stiebitz, Gerhard Bytof, Ingo Lantz, Roman Lang, Thomas Hofmann, Doris Marko
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Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Ute Boettler et al. Mol Nutr Food Res. 2011 May.

Abstract

Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

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