Review
doi: 10.1111/j.1742-481X.2011.00771.x.
Epub 2011 Mar 30.
The evidence for the role of transforming growth factor-beta in the formation of abnormal scarring
Affiliations
- PMID: 21449929
- PMCID: PMC7950816
- DOI: 10.1111/j.1742-481X.2011.00771.x
Item in Clipboard
Review
The evidence for the role of transforming growth factor-beta in the formation of abnormal scarring
Int Wound J.
2011 Jun.
Abstract
The complex biological and physiological mechanisms that result in poor quality scarring are still not fully understood. This review looks at current evidence of the role of transforming growth factor-beta (TGFβ) in this pathological process.
© 2011 The Author. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Similar articles
-
The pathogenesis of hypertrophic/keloid scarring.Int J Oral Maxillofac Surg. 1994 Aug;23(4):232-6. doi: 10.1016/s0901-5027(05)80377-7. Int J Oral Maxillofac Surg. 1994. PMID: 7798696 Review.
-
The molecular biology of fibroproliferative disorders of the skin: potential cytokine therapeutics.Ann Plast Surg. 1994 Aug;33(2):152-4. Ann Plast Surg. 1994. PMID: 7979046 No abstract available.
-
Mathematical modelling of nitric oxide activity in wound healing can explain keloid and hypertrophic scarring.J Theor Biol. 2000 May 21;204(2):257-88. doi: 10.1006/jtbi.2000.2012. J Theor Biol. 2000. PMID: 10887905
-
Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management.Curr Opin Pediatr. 2006 Aug;18(4):396-402. doi: 10.1097/01.mop.0000236389.41462.ef. Curr Opin Pediatr. 2006. PMID: 16914994 Review.
-
Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers.Sci Rep. 2019 Feb 14;9(1):2113. doi: 10.1038/s41598-019-38572-0. Sci Rep. 2019. PMID: 30765798 Free PMC article.
Cited by
-
Keloid scarring: understanding the genetic basis, advances, and prospects.Arch Plast Surg. 2012 May;39(3):184-9. doi: 10.5999/aps.2012.39.3.184. Epub 2012 May 10. Arch Plast Surg. 2012. PMID: 22783524 Free PMC article.
-
Honokiol Alleviates Hypertrophic Scar by Targeting Transforming Growth Factor-β/Smad2/3 Signaling Pathway.Front Pharmacol. 2017 Apr 19;8:206. doi: 10.3389/fphar.2017.00206. eCollection 2017. Front Pharmacol. 2017. PMID: 28469575 Free PMC article.
-
Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury.J Burn Care Res. 2012 May-Jun;33(3):311-8. doi: 10.1097/BCR.0b013e318240541e. J Burn Care Res. 2012. PMID: 22561306 Free PMC article. Review.
-
Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway.Arch Dermatol Res. 2023 Jul;315(5):1257-1267. doi: 10.1007/s00403-022-02513-1. Epub 2022 Dec 16. Arch Dermatol Res. 2023. PMID: 36526799 Free PMC article.
-
Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions.Cells. 2022 Aug 5;11(15):2430. doi: 10.3390/cells11152430. Cells. 2022. PMID: 35954275 Free PMC article. Review.
References
-
- Broughton G II, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg 2006;117(7 Suppl):1e‐S–32e‐S. - PubMed
-
- Roberts AB, Sporn MB. Peptide growth factors and their receptors, Vol. 1. Berlin: Springer, 1990:419–72.
-
- Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB. Transforming growth factor‐beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem 1983;258:7155–60. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
